8OUA
Cereblon isoform 4 in complex with novel Benzamide-Type Cereblon Binder 11f
Summary for 8OUA
Entry DOI | 10.2210/pdb8oua/pdb |
Descriptor | Cereblon isoform 4, ZINC ION, 4-azanyl-~{N}-[(3~{S})-2,6-bis(oxidanylidene)piperidin-3-yl]-2,5-bis(fluoranyl)-3-methoxy-benzamide, ... (6 entities in total) |
Functional Keywords | cereblon, protac, e3, molecular glue, signaling protein |
Biological source | Magnetospirillum gryphiswaldense More |
Total number of polymer chains | 3 |
Total formula weight | 36219.97 |
Authors | Heim, C.,Bischof, L.,Hartmann, M.D. (deposition date: 2023-04-22, release date: 2023-11-15, Last modification date: 2023-11-22) |
Primary citation | Steinebach, C.,Bricelj, A.,Murgai, A.,Sosic, I.,Bischof, L.,Ng, Y.L.D.,Heim, C.,Maiwald, S.,Proj, M.,Voget, R.,Feller, F.,Kosmrlj, J.,Sapozhnikova, V.,Schmidt, A.,Zuleeg, M.R.,Lemnitzer, P.,Mertins, P.,Hansen, F.K.,Gutschow, M.,Kronke, J.,Hartmann, M.D. Leveraging Ligand Affinity and Properties: Discovery of Novel Benzamide-Type Cereblon Binders for the Design of PROTACs. J.Med.Chem., 66:14513-14543, 2023 Cited by PubMed: 37902300DOI: 10.1021/acs.jmedchem.3c00851 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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