8OTL
structure of InhA from Mycobacterium tuberculosis in complex with 5-(((4-(2-hydroxyphenoxy)benzyl)(octyl)amino)methyl)-2-phenoxyphenol
Summary for 8OTL
Entry DOI | 10.2210/pdb8otl/pdb |
Descriptor | Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ACETATE ION, ... (6 entities in total) |
Functional Keywords | enoyl-acp-reductase type ii fatty acid synthase mycolic acids tuberculosis therapeutic target, oxidoreductase |
Biological source | Mycobacterium tuberculosis |
Total number of polymer chains | 6 |
Total formula weight | 177770.79 |
Authors | Tamhaev, R.,Maveyraud, L.,Chebaiki, M.,Lherbet, C.,Mourey, L. (deposition date: 2023-04-21, release date: 2024-01-24) |
Primary citation | Tamhaev, R.,Grosjean, E.,Ahamed, H.,Chebaiki, M.,Rodriguez, F.,Recchia, D.,Degiacomi, G.,Pasca, M.R.,Maveyraud, L.,Mourey, L.,Lherbet, C. Exploring the plasticity of the InhA substrate-binding site using new diaryl ether inhibitors. Bioorg.Chem., 143:107032-107032, 2023 Cited by PubMed: 38128204DOI: 10.1016/j.bioorg.2023.107032 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.108 Å) |
Structure validation
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