8OR1
Co-crystal strucutre of PD-L1 with low molecular weight inhibitor
Summary for 8OR1
Entry DOI | 10.2210/pdb8or1/pdb |
Descriptor | Programmed cell death 1 ligand 1, 5-[[5-[[2-chloranyl-3-(2-fluorophenyl)phenyl]methoxy]-2-[(~{E})-2-hydroxyethyliminomethyl]phenoxy]methyl]pyridine-3-carbonitrile (2 entities in total) |
Functional Keywords | pd-l1, inhibitor, immunotheraphy, immune system |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 26980.38 |
Authors | Zhang, H.,Zhou, S.,Wu, C.,Zhu, M.,Yu, Q.,Wang, X.,Awadasseid, A.,Plewka, J.,Magiera-Mularz, K.,Wu, Y.,Zhang, W. (deposition date: 2023-04-12, release date: 2023-08-02, Last modification date: 2023-08-23) |
Primary citation | Zhang, H.,Zhou, S.,Plewka, J.,Wu, C.,Zhu, M.,Yu, Q.,Musielak, B.,Wang, X.,Awadasseid, A.,Magiera-Mularz, K.,Wu, Y.,Zhang, W. Design, Synthesis, and Antitumor Activity Evaluation of 2-Arylmethoxy-4-(2,2'-dihalogen-substituted biphenyl-3-ylmethoxy) Benzylamine Derivatives as Potent PD-1/PD-L1 Inhibitors. J.Med.Chem., 66:10579-10603, 2023 Cited by PubMed: 37496104DOI: 10.1021/acs.jmedchem.3c00731 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.5 Å) |
Structure validation
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