8KH6

Crystal structure of FGFR4 kinase domain with 8r

Summary for 8KH6

• Entry DOI: 10.2210/pdb8kh6/pdb
• Descriptor: Fibroblast growth factor receptor 4, SULFATE ION, 1-[4-[(1~{R})-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-5-cyano-pyridin-2-yl]-3-[5-bromanyl-6-(hydroxymethyl)-3-methoxy-pyridin-2-yl]urea, ... (5 entities in total)
• Functional Keywords: complex, transferase, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 35421.40

Authors

Lin, Q.M.,Chen, X.J.,Chen, Y.H. (deposition date: 2023-08-21, release date: 2024-07-31)

• Primary citation: Yang, F.,Lin, Q.,Song, X.,Huang, H.,Chen, X.,Tan, J.,Li, Y.,Zhou, Y.,Tu, Z.,Du, H.,Zhang, Z.M.,Ortega, R.,Lin, X.,Patterson, A.V.,Smaill, J.B.,Chen, Y.,Lu, X.; Discovery of 6-Formylpyridyl Urea Derivatives as Potent Reversible-Covalent Fibroblast Growth Factor Receptor 4 Inhibitors with Improved Anti-Hepatocellular Carcinoma Activity.; J.Med.Chem., 67:2667-2689, 2024; PubMed: 38348819; DOI: 10.1021/acs.jmedchem.3c01810

Experimental method

X-RAY DIFFRACTION (1.62 Å)