8KCU

Cryo-EM structure of human gamma-secretase in complex with MK-0752

Summary for 8KCU

• Entry DOI: 10.2210/pdb8kcu/pdb
• EMDB information: 37110
• Descriptor: Presenilin-1, CHOLESTEROL, Nicastrin, ... (10 entities in total)
• Functional Keywords: intramembrane protease, gamma-secretase, gamma-secretase inhibitor, membrane protein, membrane protein-hydrolase complex
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 178935.36

Authors

Guo, X.,Li, H.,Kai, U.,Yan, C.,Lei, J.,Zhou, R.,Shi, Y. (deposition date: 2023-08-08, release date: 2024-08-14)

• Primary citation: Guo, X.,Li, H.,Kai, U.,Yan, C.,Lei, J.,Zhou, R.,Shi, Y.; Structural Basis of gamma-secretase inhibition by anti-cancer clinical drugs; To Be Published,

Experimental method

ELECTRON MICROSCOPY (2.7 Å)