8KCS
Cryo-EM structure of human gamma-secretase in complex with BMS906024
Summary for 8KCS
Entry DOI | 10.2210/pdb8kcs/pdb |
EMDB information | 37108 |
Descriptor | Nicastrin, CHOLESTEROL, Presenilin-1, ... (10 entities in total) |
Functional Keywords | intramembrane protease, gamma-secretase, gamma-secretase inhibitor, membrane protein, membrane protein-hydrolase complex |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 179048.95 |
Authors | |
Primary citation | Guo, X.,Li, H.,Kai, U.,Yan, C.,Lei, J.,Zhou, R.,Shi, Y. Structural Basis of gamma-secretase inhibition by anti-cancer clinical drugs To Be Published, |
Experimental method |
Structure validation
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