8K7D
Crystal structure of human lysosomal alpha-galactosidase A in complex with (2R,3R,4S,5R)-2-(aminomethyl)-5-(hydroxymethyl)pyrrolidine-3,4-diol
Summary for 8K7D
Entry DOI | 10.2210/pdb8k7d/pdb |
Descriptor | Alpha-galactosidase A, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total) |
Functional Keywords | alpha-galactosidase, glycosidase, iminosugar, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 93854.88 |
Authors | Li, H.Y.,Huang, K.F.,Ko, T.P.,Cheng, W.C. (deposition date: 2023-07-26, release date: 2024-04-10, Last modification date: 2024-10-09) |
Primary citation | Li, H.Y.,Lin, H.Y.,Chang, S.K.,Chiu, Y.T.,Hou, C.C.,Ko, T.P.,Huang, K.F.,Niu, D.M.,Cheng, W.C. Mechanistic Insights into Dibasic Iminosugars as pH-Selective Pharmacological Chaperones to Stabilize Human alpha-Galactosidase. Jacs Au, 4:908-918, 2024 Cited by PubMed: 38559739DOI: 10.1021/jacsau.3c00684 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.61 Å) |
Structure validation
Download full validation report