8K14
X-ray crystal structure of 18a in BRD4(1)
Summary for 8K14
Entry DOI | 10.2210/pdb8k14/pdb |
Descriptor | Bromodomain-containing protein 4, 4-[8-methoxy-2-methyl-1-(1-phenylethyl)imidazo[4,5-c]quinolin-7-yl]-3,5-dimethyl-1,2-oxazole (3 entities in total) |
Functional Keywords | brd4(1), bromodomain, protein binding |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 17179.81 |
Authors | |
Primary citation | Yu, S.,Zhang, Y.,Yang, J.,Xu, H.,Lan, S.,Zhao, B.,Luo, M.,Ma, X.,Zhang, H.,Wang, S.,Shen, H.,Zhang, Y.,Xu, Y.,Li, R. Discovery of (R)-4-(8-methoxy-2-methyl-1-(1-phenylethy)-1H-imidazo[4,5-c]quinnolin-7-yl)-3,5-dimethylisoxazole as a potent and selective BET inhibitor for treatment of acute myeloid leukemia (AML) guided by FEP calculation. Eur.J.Med.Chem., 263:115924-115924, 2024 Cited by PubMed: 37992518DOI: 10.1016/j.ejmech.2023.115924 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.28 Å) |
Structure validation
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