8ILS
Cryo-EM structure of PI3Kalpha in complex with compound 17
Summary for 8ILS
Entry DOI | 10.2210/pdb8ils/pdb |
EMDB information | 35545 |
Descriptor | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, Phosphatidylinositol 3-kinase regulatory subunit alpha, N-[(2R)-1-(ethylamino)-1-oxidanylidene-3-[4-(2-quinoxalin-6-ylethynyl)phenyl]propan-2-yl]-2,3-dimethyl-quinoxaline-6-carboxamide, ... (4 entities in total) |
Functional Keywords | phosphoinositide 3-kinase, drug target, ligand, binding pocket, chemical scaffold, structural protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 211974.38 |
Authors | Zhou, Q.,Liu, X.,Neri, D.,Li, W.,Favalli, N.,Bassi, G.,Yang, S.,Yang, D.,Vogt, P.K.,Wang, M.-W. (deposition date: 2023-03-04, release date: 2023-09-13) |
Primary citation | Zhou, Q.,Liu, X.,Neri, D.,Li, W.,Favalli, N.,Bassi, G.,Yang, S.,Yang, D.,Vogt, P.K.,Wang, M.W. Structural insights into the interaction of three Y-shaped ligands with PI3K alpha. Proc.Natl.Acad.Sci.USA, 120:e2304071120-e2304071120, 2023 Cited by PubMed: 37585458DOI: 10.1073/pnas.2304071120 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.1 Å) |
Structure validation
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