8IKH
Cryo-EM structure of human receptor with G proteins
Summary for 8IKH
Entry DOI | 10.2210/pdb8ikh/pdb |
EMDB information | 35512 |
Descriptor | Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total) |
Functional Keywords | membrane protein, complex, allosteric modulator |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 5 |
Total formula weight | 151595.20 |
Authors | Shen, S.Y.,Shao, Z.H. (deposition date: 2023-02-28, release date: 2024-06-05, Last modification date: 2024-07-17) |
Primary citation | Shen, S.,Wu, C.,Lin, G.,Yang, X.,Zhou, Y.,Zhao, C.,Miao, Z.,Tian, X.,Wang, K.,Yang, Z.,Liu, Z.,Guo, N.,Li, Y.,Xia, A.,Zhou, P.,Liu, J.,Yan, W.,Ke, B.,Yang, S.,Shao, Z. Structure-based identification of a G protein-biased allosteric modulator of cannabinoid receptor CB1. Proc.Natl.Acad.Sci.USA, 121:e2321532121-e2321532121, 2024 Cited by PubMed: 38830102DOI: 10.1073/pnas.2321532121 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.3 Å) |
Structure validation
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