8HTS
Crystal structure of Bcl2 in complex with S-10r
Summary for 8HTS
Entry DOI | 10.2210/pdb8hts/pdb |
Descriptor | Apoptosis regulator Bcl-2, 4-[2-[(2~{S})-2-(2-cyclopropylphenyl)pyrrolidin-1-yl]-7-azaspiro[3.5]nonan-7-yl]-~{N}-[3-nitro-4-(oxan-4-ylmethylamino)phenyl]sulfonyl-2-(1~{H}-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide (3 entities in total) |
Functional Keywords | inhibitor, apoptosis |
Biological source | Homo sapiens |
Total number of polymer chains | 1 |
Total formula weight | 20629.04 |
Authors | |
Primary citation | Guo, Y.,Xue, H.,Hu, N.,Liu, Y.,Sun, H.,Yu, D.,Qin, L.,Shi, G.,Wang, F.,Xin, L.,Sun, W.,Zhang, F.,Song, X.,Li, S.,Wei, Q.,Guo, Y.,Li, Y.,Liu, X.,Chen, S.,Zhang, T.,Wu, Y.,Su, D.,Zhu, Y.,Xu, A.,Xu, H.,Yang, S.,Zheng, Z.,Liu, J.,Yang, X.,Yuan, X.,Hong, Y.,Sun, X.,Guo, Y.,Zhou, C.,Liu, X.,Wang, L.,Wang, Z. Discovery of the Clinical Candidate Sonrotoclax (BGB-11417), a Highly Potent and Selective Inhibitor for Both WT and G101V Mutant Bcl-2. J.Med.Chem., 67:7836-7858, 2024 Cited by PubMed: 38695063DOI: 10.1021/acs.jmedchem.4c00027 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.25 Å) |
Structure validation
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