8FTQ

Crystal structure of hRpn13 Pru domain in complex with Ubiquitin and XL44

Summary for 8FTQ

Entry DOI	10.2210/pdb8ftq/pdb
Descriptor	Proteasomal ubiquitin receptor ADRM1, Ubiquitin, N-(3-{[(3R)-5-fluoro-2-oxo-2,3-dihydro-1H-indol-3-yl]methyl}phenyl)-4-methoxybenzamide, ... (4 entities in total)
Functional Keywords	proteasome, rpn13, protac, protein binding
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	50387.26
Authors	Walters, K.J.,Lu, X.,Chandravanshi, M. (deposition date: 2023-01-13, release date: 2024-03-27, Last modification date: 2024-04-03)
Primary citation	Lu, X.,Chandravanshi, M.,Sabbasani, V.R.,Gaikwad, S.,Hughitt, V.K.,Gyabaah-Kessie, N.,Scroggins, B.T.,Das, S.,Myint, W.,Clapp, M.E.,Schwieters, C.D.,Dyba, M.A.,Bolhuis, D.L.,Koscielniak, J.W.,Andresson, T.,Emanuele, M.J.,Brown, N.G.,Matsuo, H.,Chari, R.,Citrin, D.E.,Mock, B.A.,Swenson, R.E.,Walters, K.J. A structure-based designed small molecule depletes hRpn13 Pru and a select group of KEN box proteins. Nat Commun, 15:2485-2485, 2024 Cited by PubMed: 38509117 DOI: 10.1038/s41467-024-46644-7 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation