8FO4

Structure of full-length amyloidogenic immunoglobulin light chain H9 in complex with 6-methyl-2-(2-((1E,2E)-3-(2-nitrophenyl)allylidene)hydrazineyl)pyrimidin-4-ol

Summary for 8FO4

Entry DOI	10.2210/pdb8fo4/pdb
Descriptor	H9 immunoglobulin light chain, 6-methyl-2-{2-[(1E)-3-(2-nitrophenyl)prop-1-en-1-yl]hydrazinyl}pyrimidin-4(5H)-one, PHOSPHATE ION, ... (4 entities in total)
Functional Keywords	light chain, amyloidosis, stabilizer, immune system
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	90991.18
Authors	Yan, N.L.,Wilson, I.A.,Kelly, J.W. (deposition date: 2022-12-29, release date: 2023-05-24, Last modification date: 2024-10-23)
Primary citation	Yan, N.L.,Wilson, I.A.,Kelly, J.W. Crystal Structures of Diaryl Hydrazone and Sulfone Stabilizers in Complex with an Amyloidogenic Light Chain Reveal an Alternate Ligand-Binding Cavity Isr.J.Chem., 2023 Cited by DOI: 10.1002/ijch.202300002 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation