8FMU
Crystal structure of human Brachyury G177D variant in complex with SJF-4601
This is a non-PDB format compatible entry.
Summary for 8FMU
Entry DOI | 10.2210/pdb8fmu/pdb |
Descriptor | T-box transcription factor T, N-(3-chloro-4-fluorophenyl)-3-[4-(dimethylamino)butanamido]-4-methoxybenzamide (3 entities in total) |
Functional Keywords | brachyury, t-box transcription factor, tbxt, tbxt c006, sjf-4601, transcription |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 44976.52 |
Authors | Bebenek, A.,Linhares, B.,Jaime-Figueroa, S.,Butrin, A.,Crews, C. (deposition date: 2022-12-24, release date: 2024-02-28) |
Primary citation | Chase, D.,Bebenek, A.,Nie, P.,Jaime-Figueroa, S.,Butrin, A.,Castro, D.,Linhares, B.,Crews, C. Discovery and Development of the First Selective Brachyury Degrader To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.03 Å) |
Structure validation
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