8FJ4

LSD1-CoREST in complex with T108, short soaking

Summary for 8FJ4

• Entry DOI: 10.2210/pdb8fj4/pdb
• Descriptor: Lysine-specific histone demethylase 1A, REST corepressor 1, 3-[(1R,2S)-2-(cyclobutylamino)cyclopropyl]-N-phenylbenzamide, ... (4 entities in total)
• Functional Keywords: epigenetics, histone demethylase, drug resistance, covalent inhibitor, oxidoreductase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 113469.42

Authors

Caroli, J.,Mattevi, A. (deposition date: 2022-12-19, release date: 2024-06-26)

• Primary citation: Caroli, J.,Mattevi, A.; Distal drug resistance mutations promote covalent inhibitor-adduct Grob fragmentation in LSD1; to be published,

Experimental method

X-RAY DIFFRACTION (2.76 Å)