8FIW
Crystal structure of the SARS-CoV-2 (COVID-19) main protease in complex with inhibitor Jun10221
Summary for 8FIW
Entry DOI | 10.2210/pdb8fiw/pdb |
Descriptor | 3C-like proteinase nsp5, N-([1,1'-biphenyl]-4-yl)-N-[(1R)-2-oxo-2-{[(1S)-1-phenylethyl]amino}-1-(pyridin-3-yl)ethyl]prop-2-enamide, N-([1,1'-biphenyl]-4-yl)-N-[(1S)-2-oxo-2-{[(1S)-1-phenylethyl]amino}-1-(pyridin-3-yl)ethyl]prop-2-enamide (3 entities in total) |
Functional Keywords | sars-cov-2 mpro, main protease, viral protein, hydrolase-inhibitor complex, hydrolase/inhibitor |
Biological source | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2) |
Total number of polymer chains | 2 |
Total formula weight | 69035.76 |
Authors | |
Primary citation | Tan, B.,Sacco, M.,Tan, H.,Li, K.,Joyce, R.,Zhang, X.,Chen, Y.,Wang, J. Exploring diverse reactive warheads for the design of SARS-CoV-2 main protease inhibitors. Eur.J.Med.Chem., 259:115667-115667, 2023 Cited by PubMed: 37482021DOI: 10.1016/j.ejmech.2023.115667 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.54 Å) |
Structure validation
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