8FBU

Crystal structure of Cryptosporidium parvum N-myristoyltransferase with bound myristoyl-CoA and Compound-2

This is a non-PDB format compatible entry.

Summary for 8FBU

• Entry DOI: 10.2210/pdb8fbu/pdb
• Descriptor: Glycylpeptide N-tetradecanoyltransferase, TETRADECANOYL-COA, (2M)-2-[2-(piperazin-1-yl)phenyl]-N-(1,3-thiazol-2-yl)-1H-benzimidazole-4-carboxamide, ... (9 entities in total)
• Functional Keywords: nmt, inhibitor, myristoyl-coa, myrcoa, structural genomics, seattle structural genomics center for infectious disease, ssgcid, transferase, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Cryptosporidium parvum Iowa II
• Total number of polymer chains: 2
• Total formula weight: 104969.26

Authors

Staker, B.L.,Fenwick, M.K.,Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2022-11-30, release date: 2023-05-31, Last modification date: 2024-09-04)

• Primary citation: Fenwick, M.K.,Reers, A.R.,Liu, Y.,Zigweid, R.,Sankaran, B.,Shin, J.,Hulverson, M.A.,Hammerson, B.,Fernandez Alvaro, E.,Myler, P.J.,Kaushansky, A.,Van Voorhis, W.C.,Fan, E.,Staker, B.L.; Identification of and Structural Insights into Hit Compounds Targeting N -Myristoyltransferase for Cryptosporidium Drug Development.; Acs Infect Dis., 9:1821-1833, 2023; PubMed: 37722671; DOI: 10.1021/acsinfecdis.3c00151

Experimental method

X-RAY DIFFRACTION (2 Å)