8EXB
Crystal structure of CYP3A4 bound to an inhibitor
Summary for 8EXB
Entry DOI | 10.2210/pdb8exb/pdb |
Descriptor | Cytochrome P450 3A4, PROTOPORPHYRIN IX CONTAINING FE, {N-[([2,2'-bipyridin]-5-yl-kappa~2~N~1~,N~1'~)methyl]-3-(pyridin-3-yl)propanamide}bis[2-(quinolin-2-yl-kappaN)-1-benzothiophen-3-yl-kappaC~3~]iridium(1+), ... (4 entities in total) |
Functional Keywords | cytochrome p450, cyp3a4, inhibitor, complex, oxidoreductase, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 57405.55 |
Authors | Sevrioukova, I.F. (deposition date: 2022-10-25, release date: 2023-02-01, Last modification date: 2023-09-20) |
Primary citation | Denison, M.,Ahrens, J.J.,Dunbar, M.N.,Warmahaye, H.,Majeed, A.,Turro, C.,Kocarek, T.A.,Sevrioukova, I.F.,Kodanko, J.J. Dynamic Ir(III) Photosensors for the Major Human Drug-Metabolizing Enzyme Cytochrome P450 3A4. Inorg.Chem., 62:3305-3320, 2023 Cited by PubMed: 36758158DOI: 10.1021/acs.inorgchem.3c00059 PDB entries with the same primary citation |
Experimental method |
Structure validation
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