8EV2
Dual Modulators
Summary for 8EV2
Entry DOI | 10.2210/pdb8ev2/pdb |
Descriptor | Estrogen receptor, Nuclear receptor coactivator 2, (3~{a}~{R},4~{S},9~{b}~{S})-4-(2-chloranyl-4-oxidanyl-phenyl)-2,3,3~{a},4,5,9~{b}-hexahydro-1~{H}-cyclopenta[c]quinoline-8-sulfonamide, ... (5 entities in total) |
Functional Keywords | er-alpha, ligand complex, carbonic anhydrase, dna binding protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 64789.79 |
Authors | Tinivella, A.,Nwachukwu, J.C.,Angeli, A.,Foschi, F.,Benatti, A.L.,Pinzi, L.,Izard, T.,Ferraroni, M.,Rangarajan, E.S.,Christodoulou, M.,Passarella, D.,Supuran, C.,Nettles, K.W.,Rastelli, G. (deposition date: 2022-10-19, release date: 2022-12-28, Last modification date: 2023-10-25) |
Primary citation | Tinivella, A.,Nwachukwu, J.C.,Angeli, A.,Foschi, F.,Benatti, A.L.,Pinzi, L.,Izard, T.,Ferraroni, M.,Erumbi, R.,Christodoulou, M.S.,Passarella, D.,Supuran, C.T.,Nettles, K.W.,Rastelli, G. Design, synthesis, biological evaluation and crystal structure determination of dual modulators of carbonic anhydrases and estrogen receptors. Eur.J.Med.Chem., 246:115011-115011, 2022 Cited by PubMed: 36516582DOI: 10.1016/j.ejmech.2022.115011 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.01 Å) |
Structure validation
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