8EPP

Cryo-EM structure of SARS-CoV-2 Spike trimer S2D14 with two RBDs in the open conformation

Summary for 8EPP

• Entry DOI: 10.2210/pdb8epp/pdb
• EMDB information: 28532
• Descriptor: Spike glycoprotein, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: glycoprotein, trimer, viral protein
• Biological source: Severe acute respiratory syndrome coronavirus 2
• Total number of polymer chains: 3
• Total formula weight: 385360.47

Authors

Williams, J.A.,Harshbarger, W. (deposition date: 2022-10-06, release date: 2023-06-21)

• Primary citation: Williams, J.A.,Biancucci, M.,Lessen, L.,Tian, S.,Balsaraf, A.,Chen, L.,Chesterman, C.,Maruggi, G.,Vandepaer, S.,Huang, Y.,Mallett, C.P.,Steff, A.M.,Bottomley, M.J.,Malito, E.,Wahome, N.,Harshbarger, W.D.; Structural and computational design of a SARS-CoV-2 spike antigen with improved expression and immunogenicity.; Sci Adv, 9:eadg0330-eadg0330, 2023; PubMed: 37285422; DOI: 10.1126/sciadv.adg0330

Experimental method

ELECTRON MICROSCOPY (3.1 Å)