8ELQ

Crystal structure of SARS-CoV-2 spike protein receptor-binding domain in complex with antibody CC12.1 Fab and nanobody Nb-C4-255

Summary for 8ELQ

Entry DOI	10.2210/pdb8elq/pdb
Descriptor	Spike protein S1, Nanobody Nb-C4-255, CC12.1 Fab heavy chain, ... (6 entities in total)
Functional Keywords	synthetic, nanobody, sars-cov-2, coronavirus, neutralization, immune system, viral protein-immune system complex, viral protein/immune system
Biological source	Severe acute respiratory syndrome coronavirus 2 More
Total number of polymer chains	4
Total formula weight	85698.32
Authors	Liu, H.,Wilson, I.A. (deposition date: 2022-09-26, release date: 2023-07-05, Last modification date: 2023-10-25)
Primary citation	Misson Mindrebo, L.,Liu, H.,Ozorowski, G.,Tran, Q.,Woehl, J.,Khalek, I.,Smith, J.M.,Barman, S.,Zhao, F.,Keating, C.,Limbo, O.,Verma, M.,Liu, J.,Stanfield, R.L.,Zhu, X.,Turner, H.L.,Sok, D.,Huang, P.S.,Burton, D.R.,Ward, A.B.,Wilson, I.A.,Jardine, J.G. Fully synthetic platform to rapidly generate tetravalent bispecific nanobody-based immunoglobulins. Proc.Natl.Acad.Sci.USA, 120:e2216612120-e2216612120, 2023 Cited by PubMed: 37276407 DOI: 10.1073/pnas.2216612120 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.21 Å)

Structure validation