8EKD

Cryo-EM map of SARS-CoV-2 Omicron BA.2 spike in complex with 2130-1-0114-112

Summary for 8EKD

• Entry DOI: 10.2210/pdb8ekd/pdb
• EMDB information: 28199
• Descriptor: Fab LLNL-199 HC, Fab LLNL-199 LC, Spike protein S2', ... (4 entities in total)
• Functional Keywords: fab, cov2, ba.2, omicron, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 47981.70

Authors

Binshtein, E.,Crowe, J.E. (deposition date: 2022-09-20, release date: 2024-02-21, Last modification date: 2024-06-19)

• Primary citation: Desautels, T.A.,Arrildt, K.T.,Zemla, A.T.,Lau, E.Y.,Zhu, F.,Ricci, D.,Cronin, S.,Zost, S.J.,Binshtein, E.,Scheaffer, S.M.,Dadonaite, B.,Petersen, B.K.,Engdahl, T.B.,Chen, E.,Handal, L.S.,Hall, L.,Goforth, J.W.,Vashchenko, D.,Nguyen, S.,Weilhammer, D.R.,Lo, J.K.,Rubinfeld, B.,Saada, E.A.,Weisenberger, T.,Lee, T.H.,Whitener, B.,Case, J.B.,Ladd, A.,Silva, M.S.,Haluska, R.M.,Grzesiak, E.A.,Earnhart, C.G.,Hopkins, S.,Bates, T.W.,Thackray, L.B.,Segelke, B.W.,Lillo, A.M.,Sundaram, S.,Bloom, J.D.,Diamond, M.S.,Crowe Jr., J.E.,Carnahan, R.H.,Faissol, D.M.; Computationally restoring the potency of a clinical antibody against Omicron.; Nature, 629:878-885, 2024; PubMed: 38720086; DOI: 10.1038/s41586-024-07385-1

Experimental method