8EDI

Structure of C. elegans UNC-5 IG 1+2 Domains bound to Heparin dp4

Summary for 8EDI

• Entry DOI: 10.2210/pdb8edi/pdb
• Related: 8EDC 8EDK
• Descriptor: Netrin receptor unc-5, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 4-deoxy-2-O-sulfo-alpha-L-threo-hex-4-enopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, ... (4 entities in total)
• Functional Keywords: cell surface receptor, axon guidance, signaling, glycoprotein, protein binding
• Biological source: Caenorhabditis elegans
• Total number of polymer chains: 2
• Total formula weight: 48669.65

Authors

Priest, J.M.,Ozkan, E. (deposition date: 2022-09-04, release date: 2023-01-11, Last modification date: 2024-08-14)

• Primary citation: Priest, J.M.,Nichols, E.L.,Smock, R.G.,Hopkins, J.B.,Mendoza, J.L.,Meijers, R.,Shen, K.,Ozkan, E.; Structural insights into the formation of repulsive netrin guidance complexes.; Sci Adv, 10:eadj8083-eadj8083, 2024; PubMed: 38363837; DOI: 10.1126/sciadv.adj8083

Experimental method

X-RAY DIFFRACTION (2.11 Å)