8DPH
Cryo-EM structure of the 5HT2C receptor (VGV isoform) bound to lorcaserin
Summary for 8DPH
Entry DOI | 10.2210/pdb8dph/pdb |
EMDB information | 27635 |
Descriptor | 5-hydroxytryptamine receptor 2C, G-alpha subunit q (Gi2-mini-Gq chimeric), Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (7 entities in total) |
Functional Keywords | gpcr, membrane protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 5 |
Total formula weight | 156822.97 |
Authors | Gumpper, R.H.,Fay, J.F.,Roth, B.L. (deposition date: 2022-07-15, release date: 2022-08-24, Last modification date: 2022-08-31) |
Primary citation | Gumpper, R.H.,Fay, J.F.,Roth, B.L. Molecular insights into the regulation of constitutive activity by RNA editing of 5HT 2C serotonin receptors. Cell Rep, 40:111211-111211, 2022 Cited by PubMed: 35977511DOI: 10.1016/j.celrep.2022.111211 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.2 Å) |
Structure validation
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