8DHN
The N-terminal domain of PA endonuclease from the influenza H1N1 viral polymerase in complex with 6-Bromo-3-hydroxy-2-(5-methyl-1,2,4-oxadiazol-3-yl)pyridin-4(1H)-one
Summary for 8DHN
Entry DOI | 10.2210/pdb8dhn/pdb |
Related | 7V04 8CTF 8DAL 8DDB 8DDE |
Descriptor | PA endonuclease, (2P)-6-bromo-3-hydroxy-2-(5-methyl-1,2,4-oxadiazol-3-yl)pyridin-4(1H)-one, MANGANESE (II) ION, ... (4 entities in total) |
Functional Keywords | drug discovery, metal-binding pharmacophore, isosteres, influenza endonuclease, viral protein-inhibitor complex, antiviral protein, viral protein, hydrolase-inhibitor complex, hydrolase/inhibitor |
Biological source | Influenza A virus |
Total number of polymer chains | 1 |
Total formula weight | 22806.48 |
Authors | Kohlbrand, A.J.,Stokes, R.W.,Karges, J.,Seo, H.,Sankaran, B.,Cohen, S.M. (deposition date: 2022-06-27, release date: 2022-12-21, Last modification date: 2023-10-25) |
Primary citation | Stokes, R.W.,Kohlbrand, A.J.,Seo, H.,Sankaran, B.,Karges, J.,Cohen, S.M. Carboxylic Acid Isostere Derivatives of Hydroxypyridinones as Core Scaffolds for Influenza Endonuclease Inhibitors. Acs Med.Chem.Lett., 14:75-82, 2023 Cited by PubMed: 36655124DOI: 10.1021/acsmedchemlett.2c00434 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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