8CWV

Crystal structure of SARS-CoV-2 spike protein receptor-binding domain in complex with a cross-neutralizing nanobody 2-31 and a human antibody CC12.1 Fab

Summary for 8CWV

Entry DOI	10.2210/pdb8cwv/pdb
Descriptor	Spike protein S1, VHH 2-31, CC12.1 Fab heavy chain, ... (5 entities in total)
Functional Keywords	cross-neutralizing antibody; nanobody; sars-cov-2; sarbecovirus; immune system; vhh; cc12.1, immune system
Biological source	Severe acute respiratory syndrome coronavirus 2 More
Total number of polymer chains	4
Total formula weight	87716.71
Authors	Liu, H.,Wilson, I.A. (deposition date: 2022-05-19, release date: 2022-07-06, Last modification date: 2023-10-18)
Primary citation	Xiang, Y.,Huang, W.,Liu, H.,Sang, Z.,Nambulli, S.,Tubiana, J.,Williams Jr., K.L.,Duprex, W.P.,Schneidman-Duhovny, D.,Wilson, I.A.,Taylor, D.J.,Shi, Y. Superimmunity by pan-sarbecovirus nanobodies. Cell Rep, 39:111004-111004, 2022 Cited by PubMed: 35738279 DOI: 10.1016/j.celrep.2022.111004 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.51 Å)

Structure validation