8CRL
Crystal structure of LplA1 in complex with the inhibitor C3 (Listeria monocytogenes)
Summary for 8CRL
Entry DOI | 10.2210/pdb8crl/pdb |
Related | 8CRI 8CRJ |
Descriptor | lipoate--protein ligase, ~{N}-[3-[2-(6-aminopurin-9-yl)ethanoylamino]propyl]-5-[(3~{R})-1,2-dithiolan-3-yl]pentanamide, CALCIUM ION, ... (6 entities in total) |
Functional Keywords | lipoate, salvage, anti-infectives, drug development, inhibitor, ligase |
Biological source | Listeria monocytogenes |
Total number of polymer chains | 2 |
Total formula weight | 77464.68 |
Authors | Dienemann, J.-N.,Chen, S.-Y.,Hitzenberger, M.,Sievert, M.L.,Hacker, S.M.,Prigge, S.T.,Zacharias, M.,Groll, M.,Sieber, S.A. (deposition date: 2023-03-08, release date: 2023-06-07, Last modification date: 2023-09-20) |
Primary citation | Dienemann, J.N.,Chen, S.Y.,Hitzenberger, M.,Sievert, M.L.,Hacker, S.M.,Prigge, S.T.,Zacharias, M.,Groll, M.,Sieber, S.A. A Chemical Proteomic Strategy Reveals Inhibitors of Lipoate Salvage in Bacteria and Parasites. Angew.Chem.Int.Ed.Engl., 62:e202304533-e202304533, 2023 Cited by PubMed: 37249408DOI: 10.1002/anie.202304533 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
Download full validation report