8CKF
Crystal Structure of the first bromodomain of human BRD4 L94C variant in complex with racemic 3,5-dimethylisoxazol ligand
Summary for 8CKF
Entry DOI | 10.2210/pdb8ckf/pdb |
Descriptor | Bromodomain-containing protein 4, 3-(3,5-dimethyl-1,2-oxazol-4-yl)-5-[(~{R})-oxidanyl(pyridin-3-yl)methyl]phenol, 3-(3,5-dimethyl-1,2-oxazol-4-yl)-5-[(~{S})-oxidanyl(pyridin-3-yl)methyl]phenol, ... (4 entities in total) |
Functional Keywords | bromodomain, ligand, epigenetics, reader domain, transcription regulation, gene regulation |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 18153.68 |
Authors | Thomas, A.M.,McDonough, M.A.,Schiedel, M.,Conway, S.J. (deposition date: 2023-02-15, release date: 2023-08-02, Last modification date: 2023-11-29) |
Primary citation | Thomas, A.M.,Serafini, M.,Grant, E.K.,Coombs, E.A.J.,Bluck, J.P.,Schiedel, M.,McDonough, M.A.,Reynolds, J.K.,Lee, B.,Platt, M.,Sharlandjieva, V.,Biggin, P.C.,Duarte, F.,Milne, T.A.,Bush, J.T.,Conway, S.J. Mutate and Conjugate: A Method to Enable Rapid In-Cell Target Validation. Acs Chem.Biol., 18:2405-2417, 2023 Cited by PubMed: 37874862DOI: 10.1021/acschembio.3c00437 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.88 Å) |
Structure validation
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