8CH8
Crystal structure of the human PXR ligand-binding domain in complex with liranaftate
Summary for 8CH8
Entry DOI | 10.2210/pdb8ch8/pdb |
Descriptor | Nuclear receptor subfamily 1 group I member 2, ~{O}-(5,6,7,8-tetrahydronaphthalen-2-yl) ~{N}-(6-methoxypyridin-2-yl)-~{N}-methyl-carbamothioate (3 entities in total) |
Functional Keywords | nuclear receptor, pregnane x receptor, nuclear protein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 37075.89 |
Authors | Carivenc, C.,Derosa, Q.,Grimaldi, M.,Boulahtouf, A.,Balaguer, P.,Bourguet, W. (deposition date: 2023-02-07, release date: 2024-02-21) |
Primary citation | Carivenc, C.,Derosa, Q.,Grimaldi, M.,Boulahtouf, A.,Balaguer, P.,Bourguet, W. Crystal structure of the human PXR ligand-binding domain in complex with liranaftate To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
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