8CC4
LasB bound to phosphonic acid based inhibitor
Summary for 8CC4
Entry DOI | 10.2210/pdb8cc4/pdb |
Descriptor | Elastase, CALCIUM ION, [(2~{R})-4-methyl-1-oxidanylidene-1-[[4-(trifluoromethyl)phenyl]amino]pentan-2-yl]phosphonic acid, ... (5 entities in total) |
Functional Keywords | lasb, (4-methyl-1-oxo-1-((4-(trifluoromethyl)phenyl)amino)pentan-2-yl)phosphonic acid inhibitor complex, hydrolase |
Biological source | Pseudomonas aeruginosa |
Total number of polymer chains | 2 |
Total formula weight | 67240.53 |
Authors | Mueller, R.,Sikandar, A. (deposition date: 2023-01-26, release date: 2023-12-06, Last modification date: 2024-01-10) |
Primary citation | Konstantinovic, J.,Kany, A.M.,Alhayek, A.,Abdelsamie, A.S.,Sikandar, A.,Voos, K.,Yao, Y.,Andreas, A.,Shafiei, R.,Loretz, B.,Schonauer, E.,Bals, R.,Brandstetter, H.,Hartmann, R.W.,Ducho, C.,Lehr, C.M.,Beisswenger, C.,Muller, R.,Rox, K.,Haupenthal, J.,Hirsch, A.K.H. Inhibitors of the Elastase LasB for the Treatment of Pseudomonas aeruginosa Lung Infections. Acs Cent.Sci., 9:2205-2215, 2023 Cited by PubMed: 38161367DOI: 10.1021/acscentsci.3c01102 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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