8C1V

SARS-CoV-2 S-trimer (3 RBDs up) bound to TriSb92, fitted into cryo-EM map

Summary for 8C1V

• Entry DOI: 10.2210/pdb8c1v/pdb
• EMDB information: 16383
• Descriptor: Spike glycoprotein, Sb92, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• Functional Keywords: sars-cov-2 spike, sherpabody, viral protein, coronavirus
• Biological source: Severe acute respiratory syndrome coronavirus 2; More
• Total number of polymer chains: 6
• Total formula weight: 404600.45

Authors

Huiskonen, J.T.,Rissanen, I.,Hannula, L. (deposition date: 2022-12-21, release date: 2023-04-19)

• Primary citation: Makela, A.R.,Ugurlu, H.,Hannula, L.,Kant, R.,Salminen, P.,Fagerlund, R.,Maki, S.,Haveri, A.,Strandin, T.,Kareinen, L.,Hepojoki, J.,Kuivanen, S.,Levanov, L.,Pasternack, A.,Naves, R.A.,Ritvos, O.,Osterlund, P.,Sironen, T.,Vapalahti, O.,Kipar, A.,Huiskonen, J.T.,Rissanen, I.,Saksela, K.; Intranasal trimeric sherpabody inhibits SARS-CoV-2 including recent immunoevasive Omicron subvariants.; Nat Commun, 14:1637-1637, 2023; PubMed: 36964125; DOI: 10.1038/s41467-023-37290-6

Experimental method

ELECTRON MICROSCOPY (2.9 Å)