8C1H
Aurora A kinase in complex with TPX2-inhibitor 8
Summary for 8C1H
Entry DOI | 10.2210/pdb8c1h/pdb |
Descriptor | Aurora kinase A, 4-(4-chloranyl-3-pyrazin-2-yloxy-phenyl)-~{N}-(dimethylsulfamoyl)-7-methyl-1~{H}-indole-6-carboxamide, ADENOSINE-5'-DIPHOSPHATE, ... (10 entities in total) |
Functional Keywords | protein-ligand complex, kinase, protein-protein interaction inhibitor, cell cycle |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 32650.79 |
Authors | Fischer, G.,Rocaboy, M.,Blaszczyk, B.,Moschetti, T.,Wang, X.,Scott, D.E.,Coyne, A.G.,Dagostin, C.,Rooney, T.,Bayly, A.,Feng, J.,Asteian, A.,Alcaide-Lopez, A.,Stockwell, S.,Skidmore, J.,Venkitaraman, A.R.,Abell, C.,Blundell, T.L.,Hyvonen, M. (deposition date: 2022-12-20, release date: 2024-01-10, Last modification date: 2024-09-25) |
Primary citation | Stockwell, S.R.,Scott, D.E.,Fischer, G.,Guarino, E.,Rooney, T.P.C.,Feng, T.S.,Moschetti, T.,Srinivasan, R.,Alza, E.,Asteian, A.,Dagostin, C.,Alcaide, A.,Rocaboy, M.,Blaszczyk, B.,Higueruelo, A.,Wang, X.,Rossmann, M.,Perrior, T.R.,Blundell, T.L.,Spring, D.R.,McKenzie, G.,Abell, C.,Skidmore, J.,Venkitaraman, A.R.,Hyvonen, M. Selective Aurora A-TPX2 Interaction Inhibitors Have In Vivo Efficacy as Targeted Antimitotic Agents. J.Med.Chem., 67:15521-15536, 2024 Cited by PubMed: 39190548DOI: 10.1021/acs.jmedchem.4c01165 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.233 Å) |
Structure validation
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