8BX9
Crystal structure of JAK2 JH1 in complex with ilginatinib
Summary for 8BX9
Entry DOI | 10.2210/pdb8bx9/pdb |
Descriptor | Tyrosine-protein kinase JAK2, Ilginatinib, DIMETHYL SULFOXIDE, ... (4 entities in total) |
Functional Keywords | janus kinase, inhibitor complex, jak2, jh1, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 75471.69 |
Authors | Haikarainen, T. (deposition date: 2022-12-08, release date: 2023-12-20, Last modification date: 2024-07-10) |
Primary citation | Miao, Y.,Virtanen, A.,Zmajkovic, J.,Hilpert, M.,Skoda, R.C.,Silvennoinen, O.,Haikarainen, T. Functional and Structural Characterization of Clinical-Stage Janus Kinase 2 Inhibitors Identifies Determinants for Drug Selectivity. J.Med.Chem., 67:10012-10024, 2024 Cited by PubMed: 38843875DOI: 10.1021/acs.jmedchem.4c00197 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.4 Å) |
Structure validation
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