8BWF
PTBP1 RRM1 bound to an allosteric inhibitor
Summary for 8BWF
Entry DOI | 10.2210/pdb8bwf/pdb |
Descriptor | Polypyrimidine tract-binding protein 1, Ligand, SULFATE ION, ... (5 entities in total) |
Functional Keywords | rna binding, protein-peptide interaction, inhibitor, rna binding protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 32 |
Total formula weight | 181201.37 |
Authors | Schmeing, S.,Vetter, I.,t Hart, P.,Gasper, R. (deposition date: 2022-12-06, release date: 2023-10-11, Last modification date: 2023-11-15) |
Primary citation | Schmeing, S.,Amrahova, G.,Bigler, K.,Chang, J.Y.,Openy, J.,Pal, S.,Posada, L.,Gasper, R.,'t Hart, P. Rationally designed stapled peptides allosterically inhibit PTBP1-RNA-binding. Chem Sci, 14:8269-8278, 2023 Cited by PubMed: 37564416DOI: 10.1039/d3sc00985h PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
Download full validation report