8BWE

Small molecule stabilizer for 14-3-3/ChREBP (Cmd 43)

Summary for 8BWE

• Entry DOI: 10.2210/pdb8bwe/pdb
• Descriptor: 14-3-3 protein sigma, Carbohydrate-responsive element-binding protein, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: 14-3-3, chrebp, stabilization, structural protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 29388.85

Authors

Visser, E.J.,Pennings, M.A.M.,Ottmann, C. (deposition date: 2022-12-06, release date: 2024-05-01)

• Primary citation: Katz, L.S.,Visser, E.J.,Plitzko, K.F.,Pennings, M.,Cossar, P.J.,Tse, I.L.,Kaiser, M.,Brunsveld, L.,Scott, D.K.,Ottmann, C.; Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity.; Biorxiv, 2024; PubMed: 38405965; DOI: 10.1101/2024.02.16.580675

Experimental method

X-RAY DIFFRACTION (2 Å)