8BVD

FimH lectin domain in complex with mannose C-linked to quinoline

Summary for 8BVD

• Entry DOI: 10.2210/pdb8bvd/pdb
• Related: 5abz
• Descriptor: Type 1 fimbrin D-mannose specific adhesin, (2R,3S,4R,5S,6R)-2-(hydroxymethyl)-6-[(E)-3-quinolin-6-ylprop-2-enyl]oxane-3,4,5-triol (3 entities in total)
• Functional Keywords: type-1 fimbriae, escherichia coli, fimh, adhesin, lectin, anti-adhesives, c-linked mannose, cell adhesion
• Biological source: Escherichia coli UTI89
• Total number of polymer chains: 4
• Total formula weight: 68992.76

Authors

Bouckaert, J.,Bridot, C. (deposition date: 2022-12-03, release date: 2023-02-15, Last modification date: 2023-03-08)

• Primary citation: Mousavifar, L.,Sarshar, M.,Bridot, C.,Scribano, D.,Ambrosi, C.,Palamara, A.T.,Vergoten, G.,Roubinet, B.,Landemarre, L.,Bouckaert, J.,Roy, R.; Insightful Improvement in the Design of Potent Uropathogenic E. coli FimH Antagonists.; Pharmaceutics, 15:-, 2023; PubMed: 36839848; DOI: 10.3390/pharmaceutics15020527

Experimental method

X-RAY DIFFRACTION (2.995 Å)