8BTH
Notum Inhibitor ARUK3004552
Summary for 8BTH
Entry DOI | 10.2210/pdb8bth/pdb |
Descriptor | Palmitoleoyl-protein carboxylesterase NOTUM, 2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, ... (7 entities in total) |
Functional Keywords | inhibitor notum, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 44784.35 |
Authors | Zhao, Y.,Jones, E.Y.,Fish, P. (deposition date: 2022-11-28, release date: 2022-12-14, Last modification date: 2023-06-28) |
Primary citation | Atkinson, B.N.,Willis, N.J.,Zhao, Y.,Patel, C.,Frew, S.,Costelloe, K.,Magno, L.,Svensson, F.,Jones, E.Y.,Fish, P.V. Designed switch from covalent to non-covalent inhibitors of carboxylesterase Notum activity. Eur.J.Med.Chem., 251:115132-115132, 2023 Cited by PubMed: 36934521DOI: 10.1016/j.ejmech.2023.115132 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.3 Å) |
Structure validation
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