8BHO
GABA-A receptor a5 homomer - a5V3 - L655708
Summary for 8BHO
Entry DOI | 10.2210/pdb8bho/pdb |
EMDB information | 16063 |
Descriptor | Gamma-aminobutyric acid receptor subunit alpha-5, 2-acetamido-2-deoxy-beta-D-glucopyranose, ethyl (7~{S})-15-methoxy-12-oxidanylidene-2,4,11-triazatetracyclo[11.4.0.0^{2,6}.0^{7,11}]heptadeca-1(17),3,5,13,15-pentaene-5-carboxylate (3 entities in total) |
Functional Keywords | plgic gaba neurotransmission, membrane protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 5 |
Total formula weight | 208102.40 |
Authors | Miller, P.S.,Malinauskas, T.M.,Hardwick, S.W.,Chirgadze, D.Y. (deposition date: 2022-10-31, release date: 2023-11-01, Last modification date: 2023-12-27) |
Primary citation | Kasaragod, V.B.,Malinauskas, T.,Wahid, A.A.,Lengyel, J.,Knoflach, F.,Hardwick, S.W.,Jones, C.F.,Chen, W.N.,Lucas, X.,El Omari, K.,Chirgadze, D.Y.,Aricescu, A.R.,Cecere, G.,Hernandez, M.C.,Miller, P.S. The molecular basis of drug selectivity for alpha 5 subunit-containing GABA A receptors. Nat.Struct.Mol.Biol., 30:1936-1946, 2023 Cited by PubMed: 37903907DOI: 10.1038/s41594-023-01133-1 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.93 Å) |
Structure validation
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