8B8U

Crystal structure of JAK2 JH2-V617F in complex with HTS-A3

Summary for 8B8U

Entry DOI	10.2210/pdb8b8u/pdb
Descriptor	Tyrosine-protein kinase JAK2, GLYCEROL, 3,5-diphenyl-2-(trifluoromethyl)-1~{H}-pyrazolo[1,5-a]pyrimidin-7-one, ... (4 entities in total)
Functional Keywords	janus kinase, pseudokinase, inhibitor complex, jak2, jh2, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	67509.10
Authors	Haikarainen, T.,Silvennoinen, O. (deposition date: 2022-10-05, release date: 2023-02-01, Last modification date: 2024-02-07)
Primary citation	Virtanen, A.T.,Haikarainen, T.,Sampathkumar, P.,Palmroth, M.,Liukkonen, S.,Liu, J.,Nekhotiaeva, N.,Hubbard, S.R.,Silvennoinen, O. Identification of Novel Small Molecule Ligands for JAK2 Pseudokinase Domain. Pharmaceuticals, 16:-, 2023 Cited by PubMed: 36678572 DOI: 10.3390/ph16010075 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.5 Å)

Structure validation