8B75
CRYSTAL STRUCTURE OF HUMAN SOLUBLE ADENYLYL CYCLASE IN COMPLEX WITH THE INHIBITOR TDI-011861
Summary for 8B75
Entry DOI | 10.2210/pdb8b75/pdb |
Descriptor | Adenylate cyclase type 10, [(3~{R})-4-[2-[2-[[3-(2-azanyl-6-chloranyl-pyrimidin-4-yl)-1-[bis(fluoranyl)methyl]pyrazol-4-yl]methyl]phenoxy]ethyl]morpholin-3-yl]methanol (3 entities in total) |
Functional Keywords | soluble adenylyl cyclase, adcy10, signaling enzyme, class iii cyclase, signaling protein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 54764.59 |
Authors | Steegborn, C.,Kehr, M. (deposition date: 2022-09-28, release date: 2023-03-29, Last modification date: 2024-02-07) |
Primary citation | Miller, M.,Rossetti, T.,Ferreira, J.,Ghanem, L.,Balbach, M.,Kaur, N.,Levin, L.R.,Buck, J.,Kehr, M.,Coquille, S.,van den Heuvel, J.,Steegborn, C.,Fushimi, M.,Finkin-Groner, E.,Myers, R.W.,Kargman, S.,Liverton, N.J.,Huggins, D.J.,Meinke, P.T. Design, Synthesis, and Pharmacological Evaluation of Second-Generation Soluble Adenylyl Cyclase (sAC, ADCY10) Inhibitors with Slow Dissociation Rates. J.Med.Chem., 65:15208-15226, 2022 Cited by PubMed: 36346696DOI: 10.1021/acs.jmedchem.2c01133 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.82 Å) |
Structure validation
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