8AQZ
Small molecular stabilizer for ERalpha and 14-3-3 (1080267)
Summary for 8AQZ
Entry DOI | 10.2210/pdb8aqz/pdb |
Descriptor | 14-3-3 protein sigma, Estrogen receptor, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | 14-3-3, eralpha, stabilization, covalent, structural protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 27671.80 |
Authors | Visser, E.J.,Vandenboorn, E.M.F.,Ottmann, C. (deposition date: 2022-08-15, release date: 2023-09-20, Last modification date: 2023-10-04) |
Primary citation | Konstantinidou, M.,Visser, E.J.,Vandenboorn, E.,Chen, S.,Jaishankar, P.,Overmans, M.,Dutta, S.,Neitz, R.J.,Renslo, A.R.,Ottmann, C.,Brunsveld, L.,Arkin, M.R. Structure-Based Optimization of Covalent, Small-Molecule Stabilizers of the 14-3-3 sigma /ER alpha Protein-Protein Interaction from Nonselective Fragments. J.Am.Chem.Soc., 145:20328-20343, 2023 Cited by PubMed: 37676236DOI: 10.1021/jacs.3c05161 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.4 Å) |
Structure validation
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