8APV
Crystal Structure of H. influenzae TrmD in complex with Compound 27
Summary for 8APV
Entry DOI | 10.2210/pdb8apv/pdb |
Descriptor | tRNA (guanine-N(1)-)-methyltransferase, 1-[[4-(aminomethyl)phenyl]methyl]pyrrolo[2,3-b]pyridine-5-carboxamide, CITRIC ACID, ... (4 entities in total) |
Functional Keywords | methyltransferase, rna binding protein |
Biological source | Haemophilus influenzae |
Total number of polymer chains | 1 |
Total formula weight | 30222.46 |
Authors | Hall, G.,Cowan, R.,Carr, M.D. (deposition date: 2022-08-10, release date: 2023-06-14, Last modification date: 2024-02-07) |
Primary citation | Wilkinson, A.J.,Ooi, N.,Finlayson, J.,Lee, V.E.,Lyth, D.,Maskew, K.S.,Newman, R.,Orr, D.,Ansell, K.,Birchall, K.,Canning, P.,Coombs, P.,Fusani, L.,McIver, E.,Pisco, J.,Ireland, P.M.,Jenkins, C.,Norville, I.H.,Southern, S.J.,Cowan, R.,Hall, G.,Kettleborough, C.,Savage, V.J.,Cooper, I.R. Evaluating the druggability of TrmD, a potential antibacterial target, through design and microbiological profiling of a series of potent TrmD inhibitors. Bioorg.Med.Chem.Lett., 90:129331-129331, 2023 Cited by PubMed: 37187252DOI: 10.1016/j.bmcl.2023.129331 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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