8A31
p53 cancer mutant Y220C in complex with iodophenol-based small-molecule stabilizer JC694
Summary for 8A31
Entry DOI | 10.2210/pdb8a31/pdb |
Descriptor | Cellular tumor antigen p53, 4-(3-fluoranylpyrrol-1-yl)-3,5-bis(iodanyl)-2-oxidanyl-benzoic acid, ZINC ION, ... (5 entities in total) |
Functional Keywords | tumor suppressor p53, cancer mutant, drug discovery, small-molecule stabilizer, transcription |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 50230.49 |
Authors | Balourdas, D.I.,Stephenson Clarke, J.R.,Baud, M.G.J.,Knapp, S.,Joerger, A.C.,Structural Genomics Consortium (SGC) (deposition date: 2022-06-06, release date: 2022-11-30, Last modification date: 2024-01-31) |
Primary citation | Stephenson Clarke, J.R.,Douglas, L.R.,Duriez, P.J.,Balourdas, D.I.,Joerger, A.C.,Khadiullina, R.,Bulatov, E.,Baud, M.G.J. Discovery of Nanomolar-Affinity Pharmacological Chaperones Stabilizing the Oncogenic p53 Mutant Y220C. Acs Pharmacol Transl Sci, 5:1169-1180, 2022 Cited by PubMed: 36407959DOI: 10.1021/acsptsci.2c00164 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.46 Å) |
Structure validation
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