8A0V
Crystal structure of TEAD3 in complex with CPD2
Summary for 8A0V
Entry DOI | 10.2210/pdb8a0v/pdb |
Descriptor | Transcriptional enhancer factor TEF-5, MYRISTIC ACID, DIMETHYL SULFOXIDE, ... (6 entities in total) |
Functional Keywords | inhibitor, complex, transcription |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 4 |
Total formula weight | 104611.46 |
Authors | Scheufler, C.,Kallen, J. (deposition date: 2022-05-30, release date: 2022-08-17, Last modification date: 2024-05-01) |
Primary citation | Furet, P.,Bordas, V.,Le Douget, M.,Salem, B.,Mesrouze, Y.,Imbach-Weese, P.,Sellner, H.,Voegtle, M.,Soldermann, N.,Chapeau, E.,Wartmann, M.,Scheufler, C.,Fernandez, C.,Kallen, J.,Guagnano, V.,Chene, P.,Schmelzle, T. The First Class of Small Molecules Potently Disrupting the YAP-TEAD Interaction by Direct Competition. Chemmedchem, 17:e202200303-e202200303, 2022 Cited by PubMed: 35950546DOI: 10.1002/cmdc.202200303 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.699 Å) |
Structure validation
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