7ZZP

Structure of HDAC2 complexed with an inhibitory ligand

Summary for 7ZZP

Entry DOI	10.2210/pdb7zzp/pdb
Descriptor	Histone deacetylase 2, DI(HYDROXYETHYL)ETHER, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, ... (13 entities in total)
Functional Keywords	deacetylase, chromatin binding, transcription regulator, transcription
Biological source	Homo sapiens (human)
Total number of polymer chains	3
Total formula weight	172992.50
Authors	Cleasby, A.,Tisi, D. (deposition date: 2022-05-25, release date: 2022-09-21, Last modification date: 2023-11-15)
Primary citation	Tamanini, E.,Miyamura, S.,Buck, I.M.,Cons, B.D.,Dawson, L.,East, C.,Futamura, T.,Goto, S.,Griffiths-Jones, C.,Hashimoto, T.,Heightman, T.D.,Ishikawa, S.,Ito, H.,Kaneko, Y.,Kawato, T.,Kondo, K.,Kurihara, N.,McCarthy, J.M.,Mori, Y.,Nagase, T.,Nakaishi, Y.,Reeks, J.,Sato, A.,Schopf, P.,Tai, K.,Tamai, T.,Tisi, D.,Woolford, A.J. Fragment-Based Discovery of a Novel, Brain Penetrant, Orally Active HDAC2 Inhibitor. Acs Med.Chem.Lett., 13:1591-1597, 2022 Cited by PubMed: 36262388 DOI: 10.1021/acsmedchemlett.2c00272 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.52 Å)

Structure validation