7ZYW

Crystal structure of T2R-TTL-PM534 complex

Summary for 7ZYW

Entry DOI	10.2210/pdb7zyw/pdb
Descriptor	Tubulin alpha-1B chain, GUANOSINE-5'-DIPHOSPHATE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (15 entities in total)
Functional Keywords	tubulin, microtubule destabilizing agents, inhibitor, cell cycle/inhibitor, cell cycle-inhibitor complex
Biological source	Rattus norvegicus (Norway rat) More
Total number of polymer chains	6
Total formula weight	271088.10
Authors	Oliva, M.A.,Diaz, J.F.,Cuevas, C. (deposition date: 2022-05-25, release date: 2023-11-29, Last modification date: 2024-06-12)
Primary citation	Lucena-Agell, D.,Guillen, M.J.,Matesanz, R.,Alvarez-Bernad, B.,Hortiguela, R.,Aviles, P.,Martinez-Diez, M.,Santamaria-Nunez, G.,Contreras, J.,Plaza-Menacho, I.,Gimenez-Abian, J.F.,Oliva, M.A.,Cuevas, C.,Diaz, J.F. PM534, an Optimized Target-Protein Interaction Strategy through the Colchicine Site of Tubulin. J.Med.Chem., 67:2619-2630, 2024 Cited by PubMed: 38294341 DOI: 10.1021/acs.jmedchem.3c01775 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.45 Å)

Structure validation