7ZYK

Compound 9 Bound to CK2alpha

7ZYK の概要

• エントリーDOI: 10.2210/pdb7zyk/pdb
• 分子名称: Casein kinase II subunit alpha, ADENOSINE-5'-DIPHOSPHATE, 2-(5-bromanyl-6-chloranyl-1~{H}-indol-3-yl)ethanenitrile, ... (5 entities in total)
• 機能のキーワード: fragment based drug discovery, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 39964.29

構造登録者

Brear, P.,Hyvonen, M. (登録日: 2022-05-25, 公開日: 2022-12-07, 最終更新日: 2024-01-31)

• 主引用文献: Brear, P.,De Fusco, C.,Atkinson, E.L.,Iegre, J.,Francis-Newton, N.J.,Venkitaraman, A.R.,Hyvonen, M.,Spring, D.R.; A fragment-based approach leading to the discovery of inhibitors of CK2 alpha with a novel mechanism of action.; Rsc Med Chem, 13:1420-1426, 2022; PubMed: 36426237; DOI: 10.1039/d2md00161f

実験手法

X-RAY DIFFRACTION (1.31 Å)