7ZWT

Crystal structure of human BCL6 BTB domain in complex with compound 14

7ZWT の概要

• エントリーDOI: 10.2210/pdb7zwt/pdb
• 分子名称: B-cell lymphoma 6 protein, 2-[(2-chlorophenyl)amino]-~{N}-(pyridin-2-ylmethyl)-1,3-thiazole-4-carboxamide, CHLORIDE ION, ... (6 entities in total)
• 機能のキーワード: inhibitor, cancer, transcription
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 17081.49

構造登録者

Gunnell, E.A.,Le Bihan, Y.-V.,van Montfort, R.L.M. (登録日: 2022-05-19, 公開日: 2022-11-16, 最終更新日: 2024-01-31)

• 主引用文献: Pierrat, O.A.,Liu, M.,Collie, G.W.,Shetty, K.,Rodrigues, M.J.,Le Bihan, Y.V.,Gunnell, E.A.,McAndrew, P.C.,Stubbs, M.,Rowlands, M.G.,Yahya, N.,Shehu, E.,Talbot, R.,Pickard, L.,Bellenie, B.R.,Cheung, K.J.,Drouin, L.,Innocenti, P.,Woodward, H.,Davis, O.A.,Lloyd, M.G.,Varela, A.,Huckvale, R.,Broccatelli, F.,Carter, M.,Galiwango, D.,Hayes, A.,Raynaud, F.I.,Bryant, C.,Whittaker, S.,Rossanese, O.W.,Hoelder, S.,Burke, R.,van Montfort, R.L.M.; Discovering cell-active BCL6 inhibitors: effectively combining biochemical HTS with multiple biophysical techniques, X-ray crystallography and cell-based assays.; Sci Rep, 12:18633-18633, 2022; PubMed: 36329085; DOI: 10.1038/s41598-022-23264-z

実験手法

X-RAY DIFFRACTION (1.94 Å)