7ZWE

The Crystal structure of GW8695 bound to CK2alpha

Summary for 7ZWE

Entry DOI	10.2210/pdb7zwe/pdb
Descriptor	Casein kinase II subunit alpha, 7-(1~{H}-indol-2-yl)-5-methyl-~{N}-(3,4,5-trimethoxyphenyl)imidazo[5,1-f][1,2,4]triazin-2-amine (3 entities in total)
Functional Keywords	selective kinase inhibitors, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	39374.77
Authors	Brear, P.,Hyvonen, M. (deposition date: 2022-05-19, release date: 2023-05-31, Last modification date: 2024-05-15)
Primary citation	Reinecke, M.,Brear, P.,Vornholz, L.,Berger, B.T.,Seefried, F.,Wilhelm, S.,Samaras, P.,Gyenis, L.,Litchfield, D.W.,Medard, G.,Muller, S.,Ruland, J.,Hyvonen, M.,Wilhelm, M.,Kuster, B. Chemical proteomics reveals the target landscape of 1,000 kinase inhibitors. Nat.Chem.Biol., 20:577-585, 2024 Cited by PubMed: 37904048 DOI: 10.1038/s41589-023-01459-3 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.47 Å)

Structure validation