7ZWB
human Carbonic Anhydrase II in complex with 4-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)thio)benzenesulfonamide
This is a non-PDB format compatible entry.
Summary for 7ZWB
Entry DOI | 10.2210/pdb7zwb/pdb |
Descriptor | Carbonic anhydrase 2, ZINC ION, 4-[(2~{S},3~{R},4~{S},5~{S},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]sulfanylbenzenesulfonamide, ... (4 entities in total) |
Functional Keywords | carbonic anhydrase, inhibitor, metalloenzyme, sulfonamide, glucose, lyase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 30057.26 |
Authors | Angeli, A.,Ferraroni, M. (deposition date: 2022-05-19, release date: 2023-05-31, Last modification date: 2024-06-12) |
Primary citation | Angeli, A.,Ferraroni, M.,Granchi, C.,Minutolo, F.,Chen, X.,Shriwas, P.,Russo, E.,Leo, A.,Selleri, S.,Carta, F.,Supuran, C.T. First-in-Class Dual Targeting Compounds for the Management of Seizures in Glucose Transporter Type 1 Deficiency Syndrome. J.Med.Chem., 66:10010-10026, 2023 Cited by PubMed: 37436184DOI: 10.1021/acs.jmedchem.3c00938 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.48 Å) |
Structure validation
Download full validation report